Nine NCAA Division III varsity intercollegiate teams form the core of the Simmons University athletics program.

At Simmons, women athletes are the top - and only - priority in the varsity sports program. Unlike coeducational institutions where women's teams often take a back seat to the men's programs, Simmons gives its "Sharks" the best practice times, outstanding equipment and facilities, funding, and the undivided support of nearly 1,700 students who cheer on the athletes and encourage them to succeed in a spirited environment. 

Since the 1989 opening of the Holmes Sports Center, varsity sports at Simmons have grown tremendously, both in the number of programs offered and the depth of the talent among athletes. In 2016, Simmons showed its strong support toward Athletics with the opening of the $13 million outdoor athletic complex, Daly Field. The state-of-the-art facility is the "greenest" field in New England, using environment-friendly organic infill. 

While the majority of Simmons' competitive athletes are recruited out of high school, many skilled walk-ons get plenty of opportunities to play. Regardless of skill level, all Simmons athletes are students first. To enjoy the glory of athletic achievement, they must possess the desire to study and compete in an environment that rewards and respects academic excellence.

Simmons belongs to the Great Northeast Athletic Conference (GNAC), the North Atlantic Conference (NAC), the Eastern Collegiate Athletic Conference (ECAC), and is an associate member of the New England Men's and Women's Athletic Conference (NEWMAC). All teams take on worthy opponents outside the GNAC such as MIT, Tufts, Brandeis, Smith and Wellesley, among others.